I installed Nitro as a VST plugin in Nuendo 2.1.25. Whenever a window was opened or closed, the plugin caused opos and cracles. The PC, (3.06 GHz in hyperthreading mode on Asus board with 2 gigs of ram), has been 99% reliable up to the installation of Nitro. However, the PC crashed once during Sunday's session and finally it was decided that we should render the effect. That aside, this is a very, very good plugin.

Might work better with increased audio card latency (it did for me).

Seems like Nitro uses too much graphic resources. You won't see it on your Nuendo system performance bar, but closing and opening window may require quite a lot of processing. I will check if there's a possibility to make it lighter and faster... By the way - what's interesting is that nobody reported such problems with Cubase. Seems like Nuendo is much more demanding for plug-ins developers like us.