I installed Nitro as a VST plugin in Nuendo 2.1.25. Whenever a window was opened or closed, the plugin caused opos and cracles. The PC, (3.06 GHz in hyperthreading mode on Asus board with 2 gigs of ram), has been 99% reliable up to the installation of Nitro. However, the PC crashed once during Sunday's session and finally it was decided that we should render the effect. That aside, this is a very, very good plugin.