Well, here is one way to reproduce it.
Open a new project, add a track and stick three Nitros as inserts on this track.
Don't hit play or anything - just repeatedly open and close the Nitro windows and after about 10 clicks, the whole lot will either freeze completely/generate a neundo2.log or generate a windows error.
So, no audio playing, no preset changes, just opening and closing the Nitro windows causes this.